Method Validation for Determination of Metformin Hydrochloride in Pharmaceutical Formulations by Capillary Electrophoresis with Capacitively Coupled Contactless Conductivity Detection
نویسندگان
چکیده
منابع مشابه
High-voltage capacitively coupled contactless conductivity detection for microchip capillary electrophoresis.
Contactless conductivity detection was carried out on a planar electrophoresis device by capacitive coupling using an ac excitation voltage of 500 V(p-p) and a frequency of 100 kHz. It was possible to carry out detection in this way through a cover plate of 1 mm thickness. Better sensitivity is obtained, however, by placing the electrodes into troughs that allow tighter coupling to the separati...
متن کاملDetermination of haloacetic acids in water using solid-phase extraction/microchip capillary electrophoresis with capacitively coupled contactless conductivity detection.
Haloacetic acids (HAAs) were determined by a fast and simple analysis method based on microchip electrophoresis and capacitively coupled contactless conductivity detection (C(4)D). Two chlorinated acetic acids, dichloroacetic acid (DCAA) and TCA were detected in swimming pool water. Different BGEs were tested, and sodium carbonate was selected as BGE for the separation and detection in the repo...
متن کاملStudy of the determination of inorganic arsenic species by CE with capacitively coupled contactless conductivity detection.
The determination of arsenic(III) and arsenic(V), as inorganic arsenite and arsenate, was investigated by CE with capacitively coupled contactless conductivity detection (CE-C(4)D). It was found necessary to determine the two inorganic arsenic species separately employing two different electrolyte systems. Electrolyte solutions consisting of 50 mM CAPS/2 mM L-arginine (Arg) (pH 9.0) and of 45 m...
متن کاملA low-cost method for determination of calcium carbonate in cement by membraneless vaporization with capacitively coupled contactless conductivity detection.
This work presents a flow analysis method for direct quantitation of calcium carbonate in cement without pretreatment of the sample. The method is based on online vaporization of CO(2) gas following acidification of the sample inside a small chamber that has a flow of acceptor solution passing around it. Solubilization of the CO(2) gas into the acceptor stream changes the conductivity of the ac...
متن کاملDetermination of suxamethonium in a pharmaceutical formulation by capillary electrophoresis with contactless conductivity detection (CE-C(4)D).
A simple method based on capillary electrophoresis with a capacitively coupled contactless conductivity detector (CE-C(4)D) was developed for the determination of suxamethonium (SUX) in a pharmaceutical formulation. A hydro-organic mixture, consisting of 100mM Tris-acetate buffer at pH 4.2 and acetonitrile (90:10, v/v), was selected as background electrolyte (BGE). The applied voltage was 30kV,...
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ژورنال
عنوان ژورنال: Chemical Science International Journal
سال: 2019
ISSN: 2456-706X
DOI: 10.9734/csji/2019/v26i130081